DISP1 Antibody

Catalog Number:

25400

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q96F81
Gene ID:84976

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide near the amino terminus of human DISP1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of DISP1 are known to exist; this antibody will detect both isoforms. DISP1 antibody is predicted to not cross-react with EMX1.

Applications:

ELISA WB

Background:

DISP1 is the mammalian homolog of the Drosophila Dispatched segment-polarity gene and a key regulator of the Hedgehog (Hh) signaling pathway during embryonic development. DISP1 is required to move Shh from site of synthesis during embryogenesis; mutations in the gene result in lethality at mid-gestation and prevents specification of ventral cell types in the neural tube. Recent results have shown that DISP1 mediates the basolateral secretion of Shh and regulates growth of mammalian long bones through the control of Ihh.

References:

appl_detail:

Datasheet PDF