PRICKLE2 Antibody

Catalog Number:

25383

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q7Z3G6
Gene ID:166336

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide near the center of human PRICKLE2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Two isoforms of PRICKLE2 are known to exist. PRICKLE2 antibody is predicted to not cross-react with other PRICKLE protein family members.

Applications:

ELISA WB

Background:

PRICKLE2, also known as Pk2 or EPM5, is a member of a highly conserved protein family that function in the noncanonical WNT signaling pathway which regulates intracellular calcium release and planar cell polarity. Both PRICKLE2 and the related protein PRICKLE1 are expressed in postmitotic neurons and promote neurite outgrowth , and both proteins promote neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. PRICKLE2 localizes to the postsynaptic density and interacts with PSD-95 and NMDA receptors. Defects in the gene encoding PRICKLE2 are associated with autosomal recessive progressive myoclonic epilepsy.

References:

appl_detail:

Datasheet PDF