PRICKLE1 Antibody

Catalog Number:

25382

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q96MT3
Gene ID:144165

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 19 amino acid peptide near the carboxy terminus of human PRICKLE1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Multiple isoforms of PRICKLE1 are known to exist. PRICKLE1 antibody is predicted to not cross-react with other PRICKLE protein family members.

Applications:

ELISA WB

Background:

PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.

References:

appl_detail:

Datasheet PDF