ECRG2 Antibody

Catalog Number:

25368

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P58062
Gene ID:84651

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide near the carboxy terminus of human ECRG2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

ECRG2 antibody is predicted to not cross-react with other ECRG family members

Applications:

ELISA WB

Background:

The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.

References:

appl_detail:

Datasheet PDF