HIG2 Antibody

Catalog Number:

25358

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9BW72
Gene ID:192286

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide near the carboxy terminus of human HIG2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of HIG2 are known to exist; this antibody will detect both isoforms. HIG2 antibody is predicted to not cross-react with HIG1

Applications:

ELISA WB

Background:

HIG1 and HIG2 (Hypoxia-inducible gene 1 and 2, respectively) are known to be induced by hypoxic conditions. HIG2 is induced by hypoxia and by glucose deprivation in cultured cells. In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen. Unlike HIG2, which is ubiquitously expressed and might be an activator and target of the canonical Wnt pathway, the function and the mechanisms underlying its regulation of HIG1 still remained unknown. The putative link between hypoxia and an oncogenic signaling pathway might play an important role in tumorigenesis.

References:

appl_detail:

Datasheet PDF