EI24 Antibody

Catalog Number:

25356

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O14681
Gene ID:9538

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 19 amino acid peptide near the carboxy terminus of human EI24.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of EI24 are known to exist; this antibody will only detect the larger isoform.

Applications:

ELISA WB

Background:

The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.

References:

appl_detail:

Datasheet PDF