CCDC141 Antibody

Catalog Number:

25327

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6ZP82
Gene ID:285025

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against an 18 amino acid peptide near the amino terminus of human CCDC141.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least four isoforms of CCDC141 are known to exist.

Applications:

ELISA WB

Background:

Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.

References:

appl_detail:

Datasheet PDF