TYW4 Antibody

Catalog Number:

25317

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O60294
Gene ID:9836

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide near the amino terminus of human TYW4.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

TYW4 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW4 are known to exist; this antibody will detect only the long isoform.

Applications:

ELISA WB

Background:

TYW4 is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW4 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.

References:

appl_detail:

Datasheet PDF