Translin Antibody

Catalog Number:

25312

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q15631
Gene ID:7247

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 20 amino acid peptide near the carboxy terminus of human Translin.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of Translin are known to exist; this antibody will detect both.

Applications:

ELISA WB

Background:

Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.

References:

appl_detail:

Datasheet PDF