PRR5L Antibody

Catalog Number:

25298

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6MZQ0
Gene ID:79899

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 17 amino acid peptide near the center of human PRR5L.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least three isoforms of PRR5L are known to exist; this antibody will recognize only isoforms a and b. PRR5L antibody will not cross-react with PPR5.

Applications:

ELISA WB

Background:

Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.

References:

appl_detail:

Datasheet PDF