ATP2C2 Antibody

Catalog Number:

25296

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O75185
Gene ID:9914

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 19 amino acid peptide near the amino terminus of human ATP2C2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1

Applications:

ELISA WB

Background:

ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.

References:

appl_detail:

Datasheet PDF