N4BP1 Antibody

Catalog Number:

25259

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O75113
Gene ID:9683

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 18 amino acid peptide near the amino terminus of human N4BP1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least three isoforms of N4BP1 are known to exist; this antibody will only detect the longest isoform.

Applications:

ELISA WB

Background:

Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.

References:

appl_detail:

Datasheet PDF