KLOTHO Antibody

Catalog Number:

25237

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9UEF7
Gene ID:9365

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide near the center of human KLOTHO.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Three isoforms of KLOTHO are known to exist.

Applications:

ELISA WB IHC

Background:

KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.

References:

appl_detail:

Datasheet PDF