RBM35A Antibody

Catalog Number:

25264

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6NXG1
Gene ID:54845

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 18 amino acid peptide near the amino terminus of human RBM35A.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

RBM35A antibody is predicted to not cross-react with other RBM35/ESRP family members. At least five isoforms of RBM35A are known to exist; this antibody will detect all five.

Applications:

ELISA WB IHC

Background:

RBM35A, also known as ESRP1, is a mRNA splicing factor that with its related protein RBM35B (ESRP2) are coordinators of an epithelial cell-type-specific splicing program. RBM35A contains three putative RNA recognition motifs and acts by directly binding specific sequences in mRNAs. RBM35A is involved in posttranscriptional regulation of a number of genes such as FGFR2, CD44, CTNND1, and ENAH by exerting a differential effect on protein translation via 5' UTRs of mRNAs. Other recent studies have shown that RMB35A may also act as a novel tumor suppressor.

References:

appl_detail:

Datasheet PDF