JMJD1C Antibody

Catalog Number:

24957

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q15652
Gene ID:221037

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 20 amino acid peptide from near the amino terminus of human JMJD1C.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody will not cross-react with JMJD1A or JMJD1B.

Applications:

ELISA WB IHC

Background:

The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.

References:

appl_detail:

Datasheet PDF