FAM120A Antibody

Catalog Number:

24950

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9NZB2
Gene ID:23196

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against an 18 amino acid peptide from near the center of human FAM120A.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody will not cross-reacti with FAM120B / PGCC1.

Applications:

ELISA WB IHC

Background:

FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.

References:

appl_detail:

Datasheet PDF