IRGC Antibody

Catalog Number:

24944

Amount:

100μg

Price:

$319

Swiss-Prot No:

NP_062558

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 13 amino acid peptide near the amino terminus of human IRGC.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Two isoforms of IRGC are known to exist; this antibody will only recognize the IRGCa isoform.

Applications:

ELISA WB ICC

Background:

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.

References:

appl_detail:

Datasheet PDF