SYPL2 Antibody

Catalog Number:

24928

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q5VXT5
Gene ID:284612

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 15 amino acid peptide near the carboxy terminus of human SYPL.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.

Applications:

ELISA WB IHC

Background:

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.

References:

appl_detail:

Datasheet PDF