PCDH18 Antibody

Catalog Number:

24859

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9HCL0
Gene ID:54510

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 17 amino acid peptide near the amino terminus of human PCDH12.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least three isoforms of PCDH18 are known to exist. This antibody is predicted to not cross-react with PCDH12.

Applications:

ELISA WB IHC

Background:

Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs. Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea. PCDH18 expression is also temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development. PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, lending support to the hypothesis that PCDH18 may play a role during brain development.

References:

appl_detail:

Datasheet PDF