LZTS2 Antibody

Catalog Number:

24855

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9BRK4
Gene ID:84445

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 17 amino acid peptide near the carboxy terminus of human LZTS2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

LZTS2 antibody is predicted to not cross-react with other LZTS family members.

Applications:

ELISA IHC

Background:

The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.

References:

appl_detail:

Datasheet PDF