PCDH12 Antibody

Catalog Number:

24854

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9NPG4
Gene ID:51294

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 17 amino acid peptide near the amino terminus of human PCDH12.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody is predicted to not cross-react with PCDH18.

Applications:

ELISA WB IHC

Background:

Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.

References:

appl_detail:

Datasheet PDF