Hax1b Antibody

Catalog Number:

24725

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O00165
Gene ID:10456

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 10 amino acid peptide near the amino terminus of human Hax1b.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least four isoforms of Hax1 are known to exist. This antibody is predicted to recognize Hax1b.

Applications:

ELISA WB

Background:

The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting.

References:

appl_detail:

Datasheet PDF