SATB2 Antibody

Catalog Number:

24695

Amount:

100μg

Price:

$319

Swiss-Prot No:

Q9UPW6

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 14 amino acid peptide near the carboxy terminus of the human SATB2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of SATB2 are known to exist. This SATB2 antibody will not cross-react with SATB1.

Applications:

ELISA WB IHC

Background:

Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein. Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex. Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function. SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development.

References:

appl_detail:

Datasheet PDF