Rim2 Antibody

Catalog Number:

24685

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9UQ26
Gene ID:9699

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 17 amino acid peptide near the center of the human Rim2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody is predicted to have no cross-reactivity to other Rim proteins.

Applications:

ELISA WB IHC

Background:

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner. Rim2 is known to exist in multiple isoforms; this antibody should recognize most of them.

References:

appl_detail:

Datasheet PDF