Slitrk1 Antibody

Catalog Number:

24627

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q96PX8
Gene ID:114798

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the carboxy terminus of human Slitrk1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

Applications:

ELISA WB IHC

Background:

SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all.

References:

appl_detail:

Datasheet PDF