Grik5 Antibody

Catalog Number:

24606

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q16478
Gene ID:2901

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 17 amino acid peptide near the carboxy terminus of the human Grik5.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This Grik5 antibody does not cross-react with Grik4.

Applications:

ELISA WB IHC

Background:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.

References:

appl_detail:

Datasheet PDF