MANF Antibody

Catalog Number:

24584

Amount:

100μg

Price:

$319

Swiss-Prot No:

P55145

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 12 amino acid peptide from near the carboxy terminus of human MANF.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody does not cross-react with CDNF.

Applications:

ELISA WB IHC

Background:

MANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson’s disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.

References:

appl_detail:

Datasheet PDF