BAG3 Rabbit mAb

Catalog Number:

78925

Amount:

100μg

Price:

$318

Swiss-Prot No:

O95817

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human BAG3

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Datasheet PDF