Rad50 Rabbit mAb

Catalog Number:

78847

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q92878

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Rad50

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF