CLDN18.2 Rabbit mAb

Catalog Number:

78738

Amount:

100μg

Price:

$318

Swiss-Prot No:

P56856

Form of Antibody:

Storage/Stability:

Immunogen:

A synthetic peptide of human CLDN18.2.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

IHC

Background:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

References:

appl_detail:

IHC 1:50 - 1:200

Datasheet PDF