SLC7A11/xCT Rabbit mAb

Catalog Number:

78715

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q9UPY5

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human SLC7A11/xCT

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF