HIF1β/ARNT Rabbit mAb

Catalog Number:

78672

Amount:

100μg

Price:

$318

Swiss-Prot No:

P27540

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human HIF-1 beta.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Datasheet PDF