Phospho-AKT1-S473 Rabbit mAb

Catalog Number:

78644

Amount:

100μg

Price:

$318

Swiss-Prot No:

P31749

Form of Antibody:

Storage/Stability:

Immunogen:

A phospho specific peptide corresponding to residues surrounding S473 of human AKT1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF