ROCK1 Rabbit mAb

Catalog Number:

78609

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q13464

Form of Antibody:

Storage/Stability:

Immunogen:

Recombinant protein of human ROCK1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF