TERT Rabbit mAb

Catalog Number:

78455

Amount:

100μg

Price:

$318

Swiss-Prot No:

O14746

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human TERT.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF