NUDT5 Rabbit mAb

Catalog Number:

78437

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q9UKK9

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human NUDT5.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IF

Background:

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors.

References:

appl_detail:

WB 1:500 - 1:2000
IF 1:50 - 1:200

Datasheet PDF