ALDH2 Rabbit mAb

Catalog Number:

78415

Amount:

100μg

Price:

$318

Swiss-Prot No:

P05091

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human ALDH2

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF