[KO Validated] ITCH Rabbit mAb

Catalog Number:

78071

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q96J02

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human ITCH

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF