TIRAP Rabbit mAb

Catalog Number:

78014

Amount:

100μg

Price:

$318

Swiss-Prot No:

P58753

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human TIRAP

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Datasheet PDF