MMP14/MT1-MMP Rabbit mAb

Catalog Number:

77864

Amount:

100μg

Price:

$318

Swiss-Prot No:

P50281

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human MMP14/MMP14/MT1-MMP

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF