JAB1/CSN5/COPS5 Rabbit mAb

Catalog Number:

77859

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q92905

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human JAB1/CSN5/COPS5

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC,IF,ChIP

Background:

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
ChIP 1:50 - 1:200

Datasheet PDF