BMAL1 Rabbit mAb

Catalog Number:

77843

Amount:

100μg

Price:

$318

Swiss-Prot No:

O00327

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human BMAL1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF