UPF1/RENT1 Rabbit mAb

Catalog Number:

77815

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q92900

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human UPF1/RENT1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IF,IP

Background:

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

References:

appl_detail:

WB 1:500 - 1:2000
IF 1:50 - 1:200
IP 1:50 - 1:200

Datasheet PDF