Phospho-CRK/CRKII-Y221 Rabbit mAb

Catalog Number:

77723

Amount:

100μg

Price:

$318

Swiss-Prot No:

P46108

Form of Antibody:

Storage/Stability:

Immunogen:

A phospho specific peptide corresponding to residues surrounding Y221 of human CRK/CRKII

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF