MICA Rabbit mAb

Catalog Number:

77501

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q29983

Form of Antibody:

Storage/Stability:

Immunogen:

Recombinant protein of human MICA.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF