TTR Rabbit mAb

Catalog Number:

77315

Amount:

100μg

Price:

$318

Swiss-Prot No:

P02766

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human TTR

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF