CoA synthase (COASY） Rabbit mAb

Catalog Number:

77302

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q13057

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human CoA synthase (COASY）.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF