Presenilin 1 Rabbit mAb

Catalog Number:

77235

Amount:

100μg

Price:

$318

Swiss-Prot No:

P49768

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Presenilin 1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF