DMAP1 Rabbit mAb

Catalog Number:

77229

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q9NPF5

Form of Antibody:

Storage/Stability:

Immunogen:

Recombinant protein of human DMAP1.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF