HLA-DMB Rabbit mAb

Catalog Number:

77221

Amount:

100μg

Price:

$318

Swiss-Prot No:

P28068

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human HLA-DMB.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF